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Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region
Nevra Alkanli,
Tammam Sipahi,
Tulay Okman Kilic,
Seralp Sener
Issue:
Volume 2, Issue 4, July 2014
Pages:
49-53
Received:
19 May 2014
Accepted:
10 June 2014
Published:
30 June 2014
Abstract: The aim of this study was to investigate the distribution of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) and the distribution of Angiotensin II Type 1 Receptor A1166C (AGTR1 A1166C) gene polymorphisms in preeclamptic pregnant women comparing to control pregnant women in Turkish subjects of Trakya Region. We aimed to determine whether these polymorphisms are genetic risk factor for preeclampsia. The study included 75 preeclamptic pregnant women and 75 control pregnant women, which were categorized according to The World Health Organization Detecting Pre-eclampsia: A Practical Guide. The ACE I/D gene polymorphism was investigated using Polymerase Chain Reaction (PCR) method. The AGTR1 A1166C gene polymorphism was identified using PCR and followed by Restriction Fragment Length Polymorphism (RFLP) methods. The ACE I/D genotype distribution in preeclamptic pregnant women DD=36.0%, ID=44.0% and II=20.0% did not significantly differ from those in control pregnant women DD=38.7%, ID=50.7% and II=10.6% (P=0.279). The AGTR1 A1166C genotype distribution in preeclamptic pregnant women AA=57.3%, AC=33.4% and CC=9.3% also did not significantly differ from those in control pregnant women AA=70.7, AC=24.0% and CC=5.3% (P=0.223). This case-control study show that ACE I/D and AGTR1 A1166C gene polymorphisms are not genetic risk factors for preeclampsia in this population in Turkish pregnant women of Trakya Region.
Abstract: The aim of this study was to investigate the distribution of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) and the distribution of Angiotensin II Type 1 Receptor A1166C (AGTR1 A1166C) gene polymorphisms in preeclamptic pregnant women comparing to control pregnant women in Turkish subjects of Trakya Region. We aimed to determine whether...
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Prevalence of Iron Deficiency Anemia among Pregnant Women before Iron Supplementation in Kathmandu University Hospital/Dhulikhel Hospital
Binay Kumar Raut,
Mukesh Kumar Jha,
Abha Shrestha,
Ajya Sah,
Amit Sapkota,
Smarika Byanju,
Shyam Sundar Malla
Issue:
Volume 2, Issue 4, July 2014
Pages:
54-58
Received:
16 June 2014
Accepted:
30 June 2014
Published:
10 July 2014
Abstract: Objective: To determine the prevalence of iron deficiency anemia among pregnant women before iron supplementation in Kathmandu university Hospital/ Dhulikhel Hospital. Study area and population: Fifty three pregnant women who have not started iron supplement and attending OPD of Dhulikhel Hospital were selected for this study. Method and Material: A cluster sampling procedure was applied for this prospective and cross-sectional study. Pregnant women without any ongoing infection were selected. Sociodemographic factors, knowledge, attitude and practices of pregnant women towards iron deficiency anemia were obtained by questionnaires and blood samples were drawn. Hemoglobin, ferritin, Total serum Iron and TIBC were measured. Descriptive statistics was used for data presentation. Results: Among 53 participants overall prevalence of anemia with hemoglobin less than 11 gm/dl was 37.74%. The prevalence of IDA among pregnant women was 24.52% and the prevalence of IDA among anemic pregnant women was 65%. The percentage of anemic pregnant women with ferritin <15ng/ml was 70.00%, elevated TIBC> 400µg/dl was 65% and total serum iron < 60µg/dl was 65%. Conclusion: The 65% prevalence of IDA among anemic pregnant women in the present study suggest that there is high chance of being iron deficient in case of the anemic pregnant women who have not taken iron supplements.
Abstract: Objective: To determine the prevalence of iron deficiency anemia among pregnant women before iron supplementation in Kathmandu university Hospital/ Dhulikhel Hospital. Study area and population: Fifty three pregnant women who have not started iron supplement and attending OPD of Dhulikhel Hospital were selected for this study. Method and Material: ...
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Pregnancy Outcomes after Late Second Trimester Amniocentesis for Prenatal Diagnosis
Shauna F. Williams,
Emily Fay,
Cristina Montalvo,
Bart Holland,
Joseph J. Apuzzio
Issue:
Volume 2, Issue 4, July 2014
Pages:
59-62
Received:
15 July 2014
Accepted:
23 July 2014
Published:
30 July 2014
Abstract: Objective: To compare the rate of preterm delivery in patients who had an amniocentesis before and after 20 weeks gestation. Study Design: This is a single-center retrospective cohort study of patients referred for specialized sonogram between January 1, 2007 and December 31, 2009. Outcomes of patients who underwent amniocentesis at less than 20 0/7 weeks were compared to those who had amniocentesis on or after 20 0/7 weeks. Results: 1041 patients met the inclusion criteria, and 290 (27.9%) underwent amniocentesis. Women were younger in the late amniocentesis group and were more likely to be African-American. Gestational age at delivery, rate of preterm birth,, and birth weight did not differ between the two groups. In a multivariate analysis, gestational age at amniocentesis was not a significant factor for gestational age at delivery. Conclusion: Amniocentesis performed after 20 weeks gestation appears to be safe. This study provides reassuring information regarding late amniocentesis.
Abstract: Objective: To compare the rate of preterm delivery in patients who had an amniocentesis before and after 20 weeks gestation. Study Design: This is a single-center retrospective cohort study of patients referred for specialized sonogram between January 1, 2007 and December 31, 2009. Outcomes of patients who underwent amniocentesis at less than 20 0/...
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Institutional Delivery Service Utilization and Associated Factors among Child Bearing Age Women in Goba Woreda, Ethiopia
Daniel Bogale Odo,
Desalegn Markos Shifti
Issue:
Volume 2, Issue 4, July 2014
Pages:
63-70
Received:
19 January 2014
Accepted:
29 July 2014
Published:
10 August 2014
Abstract: In despite of skilled delivery is one of the most tracked Millennium Development Goal indicators, the proportion of births attended by skilled health personnel in Ethiopia is very low. This study aimed at assessing level of institutional delivery service utilization and associated factors among mothers who gave birth during the last twelve months prior to this study. A community based cross sectional study design which is supplemented by qualitative method was conducted on April 2013 in Goba Woreda. One urban and 8 rural smallest administrative unit (kebele) was selected using simple random sampling technique. Then, mothers were selected systematically after 580 study subjects were proportionally allocated to each kebele. Qualitative data were collected through focus group discussions (FGDs). Data were entered and analyzed using SPSS version 16.0. Frequencies, binary and multiple logistic regression analysis were done. The study indicated that 264 (47%) of the mothers delivered in health facilities. The common reasons for health facilities delivery were seeking better service (80.2%) and told to deliver on health facility by health professionals during Anti Natal Care follow up (36.1%). As compared to rural residents, urban residents were 3.6 times more likely to deliver on health facility (AOR=3.6 and 95% CI =1.86, 7.13), Anti Natal Care visit during last pregnancy (AOR=2.7 and 95% CI=1.42, 5.24) and maternal education level (AOR=3.1 and 95%CI=1.41, 6.82) had positive significant associations with institutional delivery service utilization. As compared to government strategy, institutional delivery service utilization was lower in the study area. Place of esidence, Anti Natal Care visit and maternal educational level were found to be associated with institutional delivery service utilization. Strategies with focus on increasing Anti Natal Care uptake and increasing maternal and their partners’ educational level help to increase health facility delivery service utilization.
Abstract: In despite of skilled delivery is one of the most tracked Millennium Development Goal indicators, the proportion of births attended by skilled health personnel in Ethiopia is very low. This study aimed at assessing level of institutional delivery service utilization and associated factors among mothers who gave birth during the last twelve months p...
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