Volume 7, Issue 5, September 2019, Page: 149-154
Variation Trend of Vitamin D Status in Wintertime Among Infants: A Cross-sectional Study
Wei Li, Department of Pharmacy, Maternal and Child Health Hospital of Hubei Province, Wuhan, China; Women and Children’s Hospital of Hubei Province, Wuhan, China
Qiong Dai, Women and Children’s Hospital of Hubei Province, Wuhan, China; Health Care Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, China
Yongying Qiu, Department of Gynaecology, Maternal and Child health Hospital of Xinfen County, Ganzhou, China
Jianqiong Liu, Women and Children’s Hospital of Hubei Province, Wuhan, China; Department of Child Health Care, Maternal and Child Health Hospital of Hubei Province, Wuhan, China
Yan Guo, Wuhan Centers for Disease Prevention and Control, Wuhan, China
Bin Wang, Department of Laboratory of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Received: Sep. 8, 2019;       Accepted: Sep. 25, 2019;       Published: Oct. 10, 2019
DOI: 10.11648/j.jgo.20190705.16      View  374      Downloads  150
Background The requirement of vitamin D in different stage may be diverse, but research on the variation trend of vitamin D status during infancy is scarce. Objective This study aimed to explore the variation trend of vitamin D status and influencing factors of vitamin D deficiency and insufficiency during wintertime among infants. Methods A cross-sectional study was conducted. A total of 500 infants were included in our study during January to March 2017. The serum 25(OH)D was performed by chemiluminescent assay. Multivariate Logistic regression was conducted to evaluate the influencing factors of vitamin D deficiency and vitamin D insufficiency. Results The older infants had a higher concentration of vitamin D than younger infants (r=0.62, P<0.0001). And the overall prevalence of vitamin D deficiency and insufficiency were 33.80% and 18.00%, respectively. With the increase of month age, the risk of vitamin D deficiency (OR=0.63, 95%CI: 0.57-0.70) and insufficiency (OR=0.69, 95%CI: 0.62-0.77) were both declined. In addition, the infant with low birthweight, breastfed, living in rural area were correlated with a higher risk of vitamin D deficiency and insufficiency (P<0.05). Conclusion Vitamin D deficiency and insufficiency prevalence changed with month age, routine monitoring of vitamin D levels is necessary for infant.
Vitamin D Status, Vitamin D Deficiency, Vitamin D Supplementation, Infant, Wintertime, Breastfed
To cite this article
Wei Li, Qiong Dai, Yongying Qiu, Jianqiong Liu, Yan Guo, Bin Wang, Variation Trend of Vitamin D Status in Wintertime Among Infants: A Cross-sectional Study, Journal of Gynecology and Obstetrics. Vol. 7, No. 5, 2019, pp. 149-154. doi: 10.11648/j.jgo.20190705.16
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Braegger C, Campoy C, Colomb V, Decsi T, Domellof M, Fewtrell M, et al. Vitamin D in the Healthy Paediatric Population: A Position Paper by the ESPGHAN Committee on Nutrition. Journal of pediatric gastroenterology and nutrition. 2013; 56: 692-701.
Taylor CL, Thomas PR, Aloia JF, Millard PS, Rosen CJ. Questions About Vitamin D for Primary Care Practice: Input From an NIH Conference. The American Journal of Medicine. 2015, 128:S0002934315005094.
Cashman KD, Kiely M. Towards prevention of vitamin D deficiency and beyond: knowledge gaps and research needs in vitamin D nutrition and public health. British Journal of Nutrition. 2011, 106: 1617.
Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014; 348: g2035.
Hagenau T, Vest R, Gissel T N, Poulsen CS, Erlandsen M, Mosekilde L, et al. Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporosis International 2009, 20: 133.
Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: Review of current knowledge and recommendations. Pediatrics. 2008; 122: 398-417.
Wagner CL, Greer FR. Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents. Pediatrics. 2008; 122: 1142-1152.
Jie Liu, WQ Li. A survey of Vitamin D level and the rate of Vitamin D supplementation in infants and young children in Tianjin. Journal of Applied Clinical Pediatrics. 2017; 32: 1471-1474.
Rajakumar K. Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics. 2003; 112: e132-e135.
Fiscaletti M, Stewart P, Munns CF. The importance of vitamin D in maternal and child health: a global perspective. Public Health Reviews. 2017; 38.
Manios Y, Moschonis G, Hulshof T, Bourhis A, Hull GLJ, Dowling KG, et al. Prevalence of vitamin D deficiency and insufficiency among schoolchildren in Greece: the role of sex, degree of urbanisation and seasonality. British Journal of Nutrition. 2017; 118: 550-558.
Vierucci F, Del PM, Fanos M, Gori M, Carlone G, Erba P, et al. Vitamin D status and predictors of hypovitaminosis D in Italian children and adolescents: a cross-sectional study. Eur J Pediatr. 2013; 172: 1607-1617.
Chaudhry A, Hajat S, Rizkallah N, Abu-Rub A. Risk factors for vitamin A and vitamin D deficiencies in children younger than 5 years in the occupied Palestinian territory: a cross-sectional study. Lancet. 2018; 391 Suppl 2: S3.
Kazemi A, Sharifi F, Jafari N, Mousavinasab N. High prevalence of vitamin D deficiency among pregnant women and their newborns in an Iranian population. Journal of women's health. 2009; 18: 835-839.
Dawodu A, Salameh K, Al-Janahi NSA, Reedy A. Prevalence and risk factors for low vitamin D status among breastfeeding mother-infant dyads in an environment with abundant sunshine. Int J Womens Health. 2016; 8: 529-535.
Dawodu A, Tsang RC. Maternal vitamin D status: effect on milk vitamin D content and vitamin D status of breastfeeding infants. Advances in Nutrition. 2012; 3: 353-361.
Marshall I, Mehta R, Petrova A. Vitamin D in the maternal-fetal-neonatal interface: clinical implications and requirements for supplementation. Journal of maternal-fetal & neonatal medicine. 2013; 26: 633-638.
Emmerson A, Dockery KE, Mughal MZ, Roberts SA, Tower CL, Berry JL. Vitamin D status of White pregnant women and infants at birth and 4 months in North West England: A cohort study. Matern Child Nutr. 2018; 14.
Naik P, Faridi MMA, Batra P, Madhu SV. Oral supplementation of parturient mothers with vitamin D and its effect on 25OHD status of exclusively breastfed infants at 6 months of age: A double-blind randomized placebo controlled trial. Breastfeeding medicine. 2017; 12: 621-628.
Thiele DK, Ralph J, El-Masri M, Anderson CM. Vitamin D3 supplementation during pregnancy and lactation improves vitamin D status of the mother-infant dyad. J Obstet Gynecol Neonatal Nurs. 2017; 46: 135-147.
Wang H, Xiao Y, Zhang L, Gao Q. Maternal early pregnancy vitamin D status in relation to low birth weight and small-for-gestational-age offspring. J Steroid Biochem Mol Biol. 2018; 175: 146-150.
Benjamin NS, White AJ, Vidal AC, Schildkraut JM, Murtha AP, Murphy SK, et al. Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years. Int J Obes (Lond). 2018; 42: 587-593.
Eggemoen AR, Jenum AK, Mdala I, Knutsen KV, Lagerlov P, Sletner L. Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: a longitudinal multiethnic population-based study. Br J Nutr. 2017; 117: 985-993.
Dong Y, Pollock N, Stallmann-Jorgensen IS, Gutin B, Lan L, Chen TC, et al. Low 25-hydroxyvitamin D levels in adolescents: race, season, adiposity, physical activity, and fitness. Pediatrics. 2010; 25: 1104-1111.
Black LJ, Burrows SA, Jacoby P, Oddy WH, Beilin LJ, Chan SPW, et al. Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents. Br J Nutr. 2014; 112: 1154-1162.
Bromage S, Rich-Edwards JW, Tselmen D, Baylin A, Houghton LA, Baasanjav N, et al. Seasonal epidemiology of serum 25-hydroxyvitamin D concentrations among healthy adults living in rural and urban areas in Mongolia. Nutrients. 2016; 8.
Lucas RM, Ponsonby AL, Dear K, Valery PC, Taylor B, van der Mei I, et al. Vitamin D status: multifactorial contribution of environment, genes and other factors in healthy Australian adults across a latitude gradient. J Steroid Biochem Mol Biol. 2013; 136: 300-308.
Holick MF. Vitamin D: a d-lightful solution for health. Journal of investigative medicine. 2011; 59: 872-880.
Hu Y, Chen J, Wang R, Li M, Yun C, Li W, et al. Vitamin D nutritional status and its related factors for Chinese children and adolescents in 2010-2012. Nutrients. 2017; 9.
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