Volume 7, Issue 3, May 2019, Page: 92-99
A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma
Yayoi Fukuda, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
Hitomi Nakamura, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
Keiichi Kumasawa, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Tadashi Kimura, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
Received: Mar. 27, 2019;       Accepted: May 11, 2019;       Published: Jun. 12, 2019
DOI: 10.11648/j.jgo.20190703.17      View  54      Downloads  9
Granulocyte colony-stimulating factor (G-CSF) is cytokine which belongs to the family of colony-stimulating factors and recombinant human G-CSF has been widely used in clinical practice for treating patients with neutropenia for over 20 years. Recently, it has also seen use in assisted reproductive technology (ART) treatment based on the hypothesis that G-CSF might help the uterine endometrium proliferate and prepare for implantation. However, the risk of this treatment has not been fully assessed yet and there is a potential complication with its usage. It has been reported that G-CSF stimulates cell proliferation in hematopoietic cells and various other cell types, including cancer cells, suggesting that repeated local G-CSF administration into the uterine cavity might raises the risk of contracting uterine endometrial carcinoma. Based on this hypothesis, we assessed the effect of G-CSF on human uterine carcinoma cell proliferation, using cell lines. Our study showed that G-CSF administration produced dose-dependent suppression of proliferation of human uterine endometrial carcinoma cells through a G-CSF receptor-independent mechanism via a part of mitogen-activated protein kinase (MAPK) signaling pathway. While further studies will be needed to confirm G-CSFs efficacy in improving the outcomes of ART treatment, our data at least suggests that repeated G-CSF administration does not increase the risk of uterine endometrial carcinoma and may even lower it.
Granulocyte Colony-stimulating Factor (G-CSF), Uterine Endometrial Carcinoma, Assisted Reproductive Technology (ART) Treatment
To cite this article
Yayoi Fukuda, Hitomi Nakamura, Keiichi Kumasawa, Tadashi Kimura, A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma, Journal of Gynecology and Obstetrics. Vol. 7, No. 3, 2019, pp. 92-99. doi: 10.11648/j.jgo.20190703.17
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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