Volume 7, Issue 2, March 2019, Page: 46-50
Pemphigoid Gestationis in a 15 Year Old Pregnant Patient, A Case Report and Literature Review
Emile Dabaj, Department of Obstetrics and Gynecology, St George Hospital University Medical Center, University of Balamand, Beirut, Lebanon
Jana Abdo, Department of Obstetrics and Gynecology, St George Hospital University Medical Center, University of Balamand, Beirut, Lebanon
Stephanie Yacoub, Department of Obstetrics and Gynecology, St George Hospital University Medical Center, University of Balamand, Beirut, Lebanon
Rawad Halimeh, Department of Obstetrics and Gynecology, St George Hospital University Medical Center, University of Balamand, Beirut, Lebanon
Zarouhie Bedoyan, Department of Pathology, St George Hospital University Medical Center, University of Balamand, Beirut, Lebanon
Joe Khalifeh, Department of Obstetrics and Gynecology, St George Hospital University Medical Center, University of Balamand, Beirut, Lebanon
Received: Feb. 5, 2019;       Accepted: Mar. 25, 2019;       Published: May 8, 2019
DOI: 10.11648/j.jgo.20190702.14      View  87      Downloads  39
Abstract
Pemphigoid gestationis, previously known as herpes gestationis, is a rare autoimmune bullous disease that manifests in pregnancy. Upon presentation, patients complain of intense pruritis, urticarial plaques, vesicles and bullae that primarily affect the peri-umbilical area before spreading to involve the rest of the body. The accurate diagnosis of pemphigoid gestationis is made histopathologically on biopsies, based on the presence of sub-epidermal vesicles, as well as direct visualization of linear deposition of C3 at the basement membrane zone by using immunofluorescence staining on those biopsies. The mainstay treatment of the disease remains corticosteroids. Prompt recognition and provision of the appropriate management allow a reduction in both maternal morbidity as well as fetal adverse perinatal outcomes. Pathologic skin dermatoses and diseases of pregnancy are rare and have different presentations, treatment and prognoses. This literature review includes an up to date comparison on the presentation, diagnosis and treatment of dermatoses in pregnancy, in order to help with the discrimination. A case of pemphigoid gestationis in a 15 year old woman is described. This is the youngest reported age of presentation of pemphigoid gestationis, raising the question of whether maternal age is a factor that can affect the course and the severity of the disease.
Keywords
Pemphigoid Gestationis (PG), Herpes Gestationis, Pregnancy, Pruritis, Autoimmune, Major Histocompatibility Complex (MHC)
To cite this article
Emile Dabaj, Jana Abdo, Stephanie Yacoub, Rawad Halimeh, Zarouhie Bedoyan, Joe Khalifeh, Pemphigoid Gestationis in a 15 Year Old Pregnant Patient, A Case Report and Literature Review, Journal of Gynecology and Obstetrics. Vol. 7, No. 2, 2019, pp. 46-50. doi: 10.11648/j.jgo.20190702.14
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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