Volume 6, Issue 1, January 2018, Page: 1-5
Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis
Raziye Desdicioglu, Obstetrics and Gynecology Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
Melahat Yildirim, Obstetrics and Gynecology Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
Betul Ozbek, Biochemistry Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
Gokhan Kılıc, Obstetrics and Gynecology Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
Ozcan Erel, Biochemistry Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
Ayse Filiz Yavuz, Obstetrics and Gynecology Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
Received: Dec. 5, 2017;       Accepted: Dec. 15, 2017;       Published: Jan. 16, 2018
DOI: 10.11648/j.jgo.20180601.11      View  2010      Downloads  124
Abstract
This study investigated the thiol-disulphide balance in vaginitis, which is a local inflammatory condition, through the use of a new method. A cross-sectional study involving 82 women (45 women with vaginitis and 37 women in control group) was conducted at Ataturk Education and Research Hospital, Ankara, Turkey from February 2016 to April 2016. Their ages varied between 19-75 years (mean: 42.8±11.6), were incorporated into the study. Thiol – disulphide parameters were measured and the obtained results were compared. The results showed that the serum disulphide level and disulphide/native thiol ratio in the group with vaginitis (p = 0.03 and p = 0.04) and the native thiol/total thiol ratio in the control group was higher (p = 0.03). In this study, it was shown that serum dynamic thiol-disulphide balance in the women with vaginitis had varied. Although vaginitis is a localized infectious inflammatory condition, the increase in the systemic oxidative stress is important. This study is the first article in the literature that investigates the relationship between dynamic thiol-disulphide balance and vaginitis.
Keywords
Disulphide, Thiol, Vaginitis
To cite this article
Raziye Desdicioglu, Melahat Yildirim, Betul Ozbek, Gokhan Kılıc, Ozcan Erel, Ayse Filiz Yavuz, Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis, Journal of Gynecology and Obstetrics. Vol. 6, No. 1, 2018, pp. 1-5. doi: 10.11648/j.jgo.20180601.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Chen Z, Zhang Z, Zhang H, Xie B. 2015 Analysis of the Oxidative Stress Status in Nonspecific Vaginitis and Its Role in Vaginal Epithelial Cells Apoptosis. BioMed research international. 2015; http://dx.doi.org/10.1155/2015/795656.
[2]
Eschenbach DA, Davick PR, Williams BL, Klebanoff SJ, Young-Smith K, Critchlow CM, et al. Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis. J Clin Microbiol 1989; 27 (2): 251-256.
[3]
Biswas S, Chida AS, Rahman I. Redox modifications of protein–thiols: emerging roles in cell signaling. Biochem Pharmacol 2006; 71 (5): 551-564.
[4]
Circu M, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010; 48 (6): 749-762.
[5]
Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014; 47 (18): 326-332.
[6]
Dogru A, Balkarli A, Cetin GY, Neselioglu S, Erel O, Tunc SE. et al. 2016. Thiol/disulphide homeostasis in patients with ankylosing spondylitis. Bosnian Journal of Basic Medical Sciences 2016; Doi: http://dx.doi.org/10.17305/bjbms.2016.1001
[7]
Yuksel M, Ates I, Kaplan M, Alisik M, Erel O, Saygili F et al. The dynamic thiol/disulphide homeostasis in inflammatory bowel disease and its relation with disease activity and pathogenesis. Int J Colorectal Dis 2016; 31 (6): 1229-1231.
[8]
Kara SS, Erel O, Demirdag TB, Cura BC, Gulhan B, Neselioglu S et al. Alteration of thiol-disulphide homeostasis in acute tonsillopharyngitis. Redox Report 2016; DOI: 10.1080/13510002.2016.1173328
[9]
Ciragil P, Kurutas EB, Gul M, Kilinc M, Aral M, Guven A. The effects of oxidative stress in urinary tract infection during pregnancy. Mediators of inflammation 2005; 5: 309-311.
[10]
Dursun E, Akaln FA, Genc T, Cinar N, Erel O, Yildiz BO. Oxidative Stress and Periodontal Disease in Obesity. Medicine 2016; 95 (12): e3136.
[11]
Cimen MYB, Kaya TI, Eskandari G, Tursen U, Ikizoglu G, Atik U. Oxidant/antioxidant status in patients with recurrent aphthous stomatitis. Clin Exp Dermatol 2003; 28 (6): 647-650.
[12]
Perihan O, Ergul KB, Neslihan D, Filiz A. The activity of adenosine deaminase and oxidative stress biomarkers in scraping samples of acne lesions. Journal of Cosmetic Dermatology 2012; 11 (4): 323-28.
[13]
Petersen EE, Magnani P. Efficacy and safety of Vitamin C vaginal tablets in the treatment of non-specific vaginitis: a randomised, double blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol 2004; 117 (1): 70-75.
[14]
Hainer BL, Gibson MV. Vaginitis: Diagnosis and Treatment. Am Fam Physician 2011; 83: 7.
[15]
Guo HY, Hu XM, Han DD, Wang ZP, Meng L. Lipid peroxidation and antioxidant status in vagina microenvironment of patients with several common vaginitis. Clin Exp Obstet Gynecol 2012; 40 (3): 331-336.
[16]
Kustimur S, Kalkanci A, Akbulut G, Gonul B, Bulduk E, Aksakal FN. et al. The effect of vaginal candidiasis on the levels of the oxidative biomarkers in plasma and tissue samples of diabetic rats. Mycopathologia 2007; 164 (5): 217-224.
[17]
Ratti BA, Godoy JSR, Mendonca PSB, Bidoia DL, Nakamura TU, Consolaro MEL, et al. Microbicidal activity of neutrophils is inhibited by isolates from recurrent vaginal candidiasis (RVVC) caused by Candida albicans through fungal thioredoxin reductase. Cell. Immunol 2015; 293 (1): 22-29.
[18]
Bogavac M, Lakic N, Simin N, Nikolic A, Sudji J, Bozin B. Bacterial vaginosis and biomarkers of oxidative stress in amniotic fluid. The Journal of Maternal-Fetal & Neonatal Medicine 2012; 25 (7): 1050-1054.
[19]
Eren Y, Dirik E, Neşelioglu S, Erel O. 2015. Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study. Acta Neurol Belg 2015; 115 (4): 643-649.
[20]
Walmsley SL, Winn LM, Harrison ML, Uetrecht JP, Wells PG. Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV-infected patients: toxicological and pathological implications. AIDS 1997; 11 (14): 1689-1697.
[21]
Yucel A, Sanhal CY, Daglar K, Kara O, Uygur D, Erel O. Thiol/disulphide homeostasis in pregnant women with Familial Mediterranean fever. Redox Report 2016; Doi: 10.1080/13510002.2016.1168590
[22]
Esen R, Aslan M, Kucukoglu ME, Cıkman A, Yakan U, Sunnetcioglu M, et al. 2015. Serum paraoxonase activity, total thiols levels, and oxidative status in patients with acute brucellosis. Wien Klin Wochenschr 2015; 127 (11-12): 427-433.
[23]
Karadag-Oncel E, Erel O. Ozsurekci Y, Caglayık-Yagci D. Kaya A. Gozel MG, et al. Plasma oxidative stress and total thiol levels in crimean-congo hemorrhagic Fever. Japanese journal of infectious diseases 2014; 67 (1): 22-26.
Browse journals by subject