Volume 3, Issue 3, May 2015, Page: 49-54
Clindamycin, Clotrimazole and Tinidazole in Mixed Vaginosis- A “Real World” Clinical Experience
Manish Maladkar, Aristo Pharmaceuticals Pvt. Ltd., 23-A Shah Industrial Estate, Andheri, Mumbai, India
Chitra Tekchandani, Aristo Pharmaceuticals Pvt. Ltd., 23-A Shah Industrial Estate, Andheri, Mumbai, India
Urja Dave, Aristo Pharmaceuticals Pvt. Ltd., 23-A Shah Industrial Estate, Andheri, Mumbai, India
Received: Feb. 17, 2015;       Accepted: Mar. 5, 2015;       Published: Apr. 23, 2015
DOI: 10.11648/j.jgo.20150303.12      View  5744      Downloads  357
Abstract
Background: Vaginal infections are among the most frequent disorders affecting a woman and comprise over 95% of lower female genital tract infections. Seventy five percent of the women world-wide suffer from vaginosis resulting from bacterial, fungal and protozoal infections. Several studies have shown that mixed vaginal infections occur frequently and hence, in co-infection, each pathogen requires specific therapy for complete eradication of concurrent manifestations. Materials and Methods: A multicenter, prospective, open-label, non-comparative clinical study was carried out in 495 patients with mixed vaginosis of bacterial, fungal and protozoal origin. A fixed dose combination of Clindamycin 100 mg, Clotrimazole 100 mg and Tinidazole 100 mg was administered intravaginally for 7 consecutive nights. Results: Treatment led to significant reduction in various symptoms of vaginal infection within 3 days of treatment initiation. On day 7 of treatment, 98.6% patients had normal and odourless vaginal discharge, the mean vaginal burning and irritation score declined by 99.2% and 99.3% respectively. Also, there was remission of vulvar, cervical and vaginal erythema in more than 98% of patients. Physicians and patients rated the treatment efficacy as good to very good improvement and tolerability to the treatment was regarded as good to excellent. No serious adverse events were reported. Conclusion: The present study demonstrates that fixed dose combination of Clindamycin, Clotrimazole and Tinidazole is effective and well tolerated in the treatment of mixed vaginosis due to bacterial, fungal and protozoal infection.
Keywords
Clindamycin, Clotrimazole, Tinidazole, Vaginosis, Candidiasis, Trichomoniasis
To cite this article
Manish Maladkar, Chitra Tekchandani, Urja Dave, Clindamycin, Clotrimazole and Tinidazole in Mixed Vaginosis- A “Real World” Clinical Experience, Journal of Gynecology and Obstetrics. Vol. 3, No. 3, 2015, pp. 49-54. doi: 10.11648/j.jgo.20150303.12
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