Research Article | | Peer-Reviewed

Connecting Links Between Diminished Ovarian Reserve and Recurrent Miscarriages

Received: 5 November 2023    Accepted: 25 November 2023    Published: 6 December 2023
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Abstract

For the past few years, the incidence of Recurrent Pregnancy Loss (RPL) has been on the rise, which not only plagues many couples who are preparing for pregnancy, but also has such a tremendous negative impact on the patients body and mind. Recurrent pregnancy loss is defined as two or more clinically confirmed pregnancy losses, including embryo and foetal loss, before 20-24 weeks of pregnancy. The diagnosis of early pregnancy loss is relatively straightforward, although progress in predicting and preventing recurrent pregnancy loss has been hampered by the lack of a standardized definition, uncertainty surrounding pathogenesis and a highly variable clinical presentation. The prognosis for couples with recurrent pregnancy loss is usually favourable, although the likelihood of a successful pregnancy depends on the age of the mother and the number of previous losses. Chromosomal errors, uterine anatomical defects, autoimmune diseases and endometrial dysfunction may contribute to recurrent pregnancy loss. As research continues, diminished ovarian reserve (DOR) is gaining more and more attention. Through reading related articles, this paper presents a review of the effect of diminished ovarian reserve on recurrent miscarriage, with the aim of exploring the relationship between DOR and RPL, and whether DOR has an impact on women's pregnancy outcomes.

Published in Journal of Gynecology and Obstetrics (Volume 11, Issue 6)
DOI 10.11648/j.jgo.20231106.14
Page(s) 152-155
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diminished Ovarian Reserve, Recurrent Pregnancy Loss, Ovarian Reserve Indicators, Pregnancy Outcome

References
[1] Alipour, F.; Rasekhjahromi, A.; Maalhagh, M.; Sobhanian, S.; Hosseinpoor, M., Comparison of Specificity and Sensitivity of AMH and FSH in Diagnosis of Premature Ovarian Failure. (1875-8630 (Electronic).
[2] ESHRE, Early pregnancy guideline development group. Recurrent Pregnancy Loss Guideline 2017, 90-92.
[3] RCOG, The Investigation and Treatment of Couples with Recurrent First-Trimester and Second-Trimester Miscarriage. Royal College of Obstetricians and Gynaecologists 2011, In: Green-Top Guideline No. 17.
[4] Cohn, D. M.; Goddijn, M.; Middeldorp, S.; Korevaar, J. C.; Dawood, F.; Farquharson, R. G., Recurrent miscarriage and antiphospholipid antibodies: prognosis of subsequent pregnancy. J Thromb Haemost 2010, 8 (10), 2208-13.
[5] Patel, B. G.; Lessey, B. A., Clinical assessment and management of the endometrium in recurrent early pregnancy loss. Semin Reprod Med 2011, 29 (6), 491-506.
[6] Ali, O.; Hakimi, I.; Chanana, A.; Habib, M. A. B.; Guelzim, K.; Kouach, J.; Rahali, D. M., Grossesse sur utérus cloisonné menée à terme: à propos d’un cas avec revue de la literature. Pan African Medical Journal 2015, 22 (1).
[7] Pluchino, N.; Drakopoulos, P.; Wenger, J. M.; Petignat, P.; Streuli, I.; Genazzani, A. R., Hormonal causes of recurrent pregnancy loss (RPL). Hormones 2014, 13, 314-322.
[8] Laurino, M. Y.; Bennett, R. L.; Saraiya, D. S.; Baumeister, L.; Doyle, D. L.; Leppig, K.; Pettersen, B.; Resta, R.; Shields, L.; Uhrich, S., Genetic evaluation and counseling of couples with recurrent miscarriage: recommendations of the National Society of Genetic Counselors. Journal of Genetic Counseling 2005, 14 (3), 165-181.
[9] Benedetto, C.; Tibaldi, C.; Marozio, L.; Marini, S.; Masuelli, G.; Pelissetto, S.; Sozzani, P.; Latino, M., Cervicovaginal infections during pregnancy: epidemiological and microbiological aspects. The Journal of Maternal-Fetal & Neonatal Medicine 2004, 16 (2), 9-12.
[10] Srinivas, S. K.; Ma, Y.; Sammel, M. D.; Chou, D.; McGrath, C.; Parry, S.; Elovitz, M. A., Placental inflammation and viral infection are implicated in second trimester pregnancy loss. American journal of obstetrics and gynecology 2006, 195 (3), 797-802.
[11] Kuliev, A.; Cieslak, J.; Ilkevitch, Y.; Verlinsky, Y., Chromosomal abnormalities in a series of 6733 human oocytes in preimplantation diagnosis for age-related aneuploidies. Reproductive biomedicine online 2003, 6 (1), 54-59.
[12] Munné, S.; Alikani, M.; Tomkin, G.; Grifo, J.; Cohen, J., Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities. Fertility and sterility 1995, 64 (2), 382-391.
[13] Sugiura-Ogasawara, M.; Aoki, K.; Fujii, T.; Fujita, T.; Kawaguchi, R.; Maruyama, T.; Ozawa, N.; Sugi, T.; Takeshita, T.; Saito, S., Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement. Journal of human genetics 2008, 53 (7), 622-628.
[14] Bergadá, I.; Milani, C.; Bedecarrás, P.; Andreone, L.; Ropelato, M. G.; Gottlieb, S.; Bergadá, C.; Campo, S.; Rey, R. A., Time course of the serum gonadotropin surge, inhibins, and anti-Mullerian hormone in normal newborn males during the first month of life. The Journal of Clinical Endocrinology & Metabolism 2006, 91 (10), 4092-4098.
[15] Shin, S. Y.; Lee, J. R.; Noh, G. W.; Kim, H. J.; Kang, W. J.; Kim, S. H.; Chung, J.-K., Analysis of serum levels of anti-Müllerian hormone, inhibin B, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and follicle-stimulating hormone with respect to age and menopausal status. Journal of Korean medical science 2008, 23 (1), 104-110.
[16] Lyttle Schumacher, B. M.; Jukic, A. M. Z.; Steiner, A. Z., Antimullerian hormone as a risk factor for miscarriage in naturally conceived pregnancies. Fertil Steril 2018, 109 (6), 1065-1071 e1.
[17] Atasever, M.; Soyman, Z.; Demirel, E.; Gencdal, S.; Kelekci, S., Diminished ovarian reserve: is it a neglected cause in the assessment of recurrent miscarriage? A cohort study. Fertility and Sterility 2016, 105 (5), 1236-1240.
[18] Leclercq, E.; Pasquier, E.; Le Martelot, M.; Roche, S.; Bohec, C.; Mottier, D.; Collet, M. In Is anti-Mullerian hormone, a determinant in unexplained recurrent miscarriage, Human Reproduction, OXFORD UNIV PRESS GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: 2014; pp 137-137.
[19] Nonez, H.; Rodriguez-Purata, J.; Lee, J.; Whitehouse, M.; Slifkin, R.; Moschini, R.; Duke, M.; Copperman, A.; Sandler, B.; Briton-Jones, C., Aneuploidy rates are not increased in patients with recurrent pregnancy loss. Fertility and Sterility 2016, 106 (3), e106.
[20] Hendriks, D. J.; Mol, B.-W. J.; Bancsi, L. F.; Te Velde, E. R.; Broekmans, F. J., Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle-stimulating hormone level. Fertility and sterility 2005, 83 (2), 291-301.
[21] Yildirim, G. Y.; Celik, H. G.; Koroglu, N.; Karakus, E., Do ovarian reserve markers predict the subsequent pregnancy outcomes in women with recurrent pregnancy loss? Turkish Journal of Biochemistry 2018, 43 (5), 481-486.
[22] Bunnewell, S. J.; Honess, E. R.; Karia, A. M.; Keay, S. D.; Al Wattar, B. H.; Quenby, S., Diminished ovarian reserve in recurrent pregnancy loss: a systematic review and meta-analysis. Fertility and sterility 2020, 113 (4), 818-827. e3.
[23] Mahdavipour, M.; Zarei, S.; Fatemi, R.; Edalatkhah, H.; Heidari-Vala, H.; Jeddi-Tehrani, M.; Idali, F., Polymorphisms in the estrogen receptor beta gene and the risk of unexplained recurrent spontaneous abortion. Avicenna Journal of Medical Biotechnology 2017, 9 (3), 150.
[24] Leclercq, E.; de Saint Martin, L.; Bohec, C.; Le Martelot, M. T.; Roche, S.; Alavi, Z.; Mottier, D.; Pasquier, E., Blood anti-Müllerian hormone is a possible determinant of recurrent early miscarriage, yet not conclusive in predicting a further miscarriage. Reproductive BioMedicine Online 2019, 39 (2), 304-311.
Cite This Article
  • APA Style

    Zeng, X., Zhu, Y., Lin, D. (2023). Connecting Links Between Diminished Ovarian Reserve and Recurrent Miscarriages. Journal of Gynecology and Obstetrics, 11(6), 152-155. https://doi.org/10.11648/j.jgo.20231106.14

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    ACS Style

    Zeng, X.; Zhu, Y.; Lin, D. Connecting Links Between Diminished Ovarian Reserve and Recurrent Miscarriages. J. Gynecol. Obstet. 2023, 11(6), 152-155. doi: 10.11648/j.jgo.20231106.14

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    AMA Style

    Zeng X, Zhu Y, Lin D. Connecting Links Between Diminished Ovarian Reserve and Recurrent Miscarriages. J Gynecol Obstet. 2023;11(6):152-155. doi: 10.11648/j.jgo.20231106.14

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  • @article{10.11648/j.jgo.20231106.14,
      author = {Xinfang Zeng and Yuanfang Zhu and Danmin Lin},
      title = {Connecting Links Between Diminished Ovarian Reserve and Recurrent Miscarriages},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {11},
      number = {6},
      pages = {152-155},
      doi = {10.11648/j.jgo.20231106.14},
      url = {https://doi.org/10.11648/j.jgo.20231106.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20231106.14},
      abstract = {For the past few years, the incidence of Recurrent Pregnancy Loss (RPL) has been on the rise, which not only plagues many couples who are preparing for pregnancy, but also has such a tremendous negative impact on the patients body and mind. Recurrent pregnancy loss is defined as two or more clinically confirmed pregnancy losses, including embryo and foetal loss, before 20-24 weeks of pregnancy. The diagnosis of early pregnancy loss is relatively straightforward, although progress in predicting and preventing recurrent pregnancy loss has been hampered by the lack of a standardized definition, uncertainty surrounding pathogenesis and a highly variable clinical presentation. The prognosis for couples with recurrent pregnancy loss is usually favourable, although the likelihood of a successful pregnancy depends on the age of the mother and the number of previous losses. Chromosomal errors, uterine anatomical defects, autoimmune diseases and endometrial dysfunction may contribute to recurrent pregnancy loss. As research continues, diminished ovarian reserve (DOR) is gaining more and more attention. Through reading related articles, this paper presents a review of the effect of diminished ovarian reserve on recurrent miscarriage, with the aim of exploring the relationship between DOR and RPL, and whether DOR has an impact on women's pregnancy outcomes.
    },
     year = {2023}
    }
    

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    AU  - Xinfang Zeng
    AU  - Yuanfang Zhu
    AU  - Danmin Lin
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    DO  - 10.11648/j.jgo.20231106.14
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    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
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    AB  - For the past few years, the incidence of Recurrent Pregnancy Loss (RPL) has been on the rise, which not only plagues many couples who are preparing for pregnancy, but also has such a tremendous negative impact on the patients body and mind. Recurrent pregnancy loss is defined as two or more clinically confirmed pregnancy losses, including embryo and foetal loss, before 20-24 weeks of pregnancy. The diagnosis of early pregnancy loss is relatively straightforward, although progress in predicting and preventing recurrent pregnancy loss has been hampered by the lack of a standardized definition, uncertainty surrounding pathogenesis and a highly variable clinical presentation. The prognosis for couples with recurrent pregnancy loss is usually favourable, although the likelihood of a successful pregnancy depends on the age of the mother and the number of previous losses. Chromosomal errors, uterine anatomical defects, autoimmune diseases and endometrial dysfunction may contribute to recurrent pregnancy loss. As research continues, diminished ovarian reserve (DOR) is gaining more and more attention. Through reading related articles, this paper presents a review of the effect of diminished ovarian reserve on recurrent miscarriage, with the aim of exploring the relationship between DOR and RPL, and whether DOR has an impact on women's pregnancy outcomes.
    
    VL  - 11
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Author Information
  • Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China

  • Department of Obstetrics and Gynaecology, Shenzhen Baoan Women’s and Children’s Hospital, Jinan University, Shenzhen, China

  • Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China

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